Both are great ways to sign documents electronically. Online, that is. We're talking about paperless transactions. Working from your virtual office (which can be your home-based business or your mobile office from anywhere in the world).
The great thing about DocuSign is that YOU, the real estate professional, can sign your docs; then put "sticky notes" for your clients to sign; and THEY can read & sign online too! Without ever printing out a single paper. On the "down" side, you have to pay a monthly or annual fee to continue using the service.
Here's a sample signature from DocuSign:

At the top of the page, the entire document is coded with the date, time, and computer ID of the signature. Note that each signature has a DocuSign code to verify the signer's identity.
The great thing about Adobe Acrobat is that it's FREE to use the e-signature feature once you purchase the Adobe software. There's no recurring fee. The "down" side is that EACH SIGNER must purchase a copy of the software on their computer. So it's not very helpful for getting your clients to sign docs that you send them.
Here's a sample signature from Adobe Acrobat:
Each signature is identified with the date, time, and computer ID of the signer. So it's always safe and secure.
Maybe even more fool-proof than a hand-written signature!

Regina P. Brown
Broker, Realtor®, e-Pro
Author of eBook "Stop Foreclosure Fast: Solutions to Save your House"
Author of forthcoming book, "Virtual Office Guide for Business Professionals: Work & Profit from Home"
Join & post to my NEW ActiveRain group at http://activerain.com/groups/virtualoffice
Text copyright © 2009 R.P. Brown, All Rights Reserved
Great write-up. You know your stuff! There are a few other differences to point out between DocuSign and the Adobe signing process. I know because I tried it.
1. Control, with DocuSign, you are always in control, and you can see where things are 100% of the time, it automatically reminds, and if you sent the wrong file you can pull it back. With acrobat you email the file off, and hope they can figure out how to sign. You have no idea if they got it, opened it, etc. Want to know, call them and ask? Send the wrong file, tough! Need to remind them - your time is taken for all that.
2. Multiple signers - if you need both buyers to sign, and then perhaps both sellers to sign, you can do this all on the same document, with DocuSign managing the signature collection process. With Acrobat, YOU need to be the traffic cop - first send it to buyer 1, then send to buyer 2, then once that is done, send to sellers agent/sellers - ALL MANUAL ON YOUR PART. This not only is a hassle for you, it is a major time-waster compared to DocuSign
3. Fast and Easy to sign - with DocuSign your signers just validate by email, or by access code (which I use sometimes), then click to sign, initial, or fill out info I need. As soon as one signs, it instantly goes to the next. No software to install, nothing to learn, nothing for them to buy. With Acrobat, they will be calling me to ask how to buy Acrobat, or how to make a digital certificate. It is expensive, confusing, and just distracts from the task - getting a signature.
4. Authentication - DocuSign provides a full audit trail document for each and every signer - showing important audit trail info like IP address used, email used, signature adopted, when they got it, when they signed it, what authentication they went through, etc. If you ever get asked for proof, you have it. With Acrobat you have none of this.
5. Mistake-proof signing - With DocuSign the signer MUST sign each place you ask, initial each place you ask, and they can't sign in the wrong place, or miss a page. With Acrobat they have to figure it out on their own. And easily can miss, so you have to send it again. Even better, DocuSign templates can apply ALL OF THE TABS AT ONCE, making the process of applying the digital 'sign here' tabs automatic, mistake proof, and fast.
6. The Standard - DocuSign has been adopted as the standard in Real Estate, and integrated into most of the mainstream Real Estate forms platforms making it even easier to send, and everyone trusts the system. Using something besides DocuSign is like driving on the wrong side of the road.
So, if you have a customer-centric way of working, and value your time, DocuSign is hands-down a better way to go! ESPECIALLY for Real Estate!
TJ