The software offered by my Realtor's association, OCAR, is excellent for creating CMAs. We use MLXChange.

Tom, we create flyers for our agent partners on a publisher template that pulls data from an excel spreadsheet.  They input the information on the property on my website, we import into excel, it runs the calculations for payment and what it takes to qualify for the home zero down, zero closing costs, payment, etc. Plus, the spreadsheet imports the bullet points for the home.

Then, open the publisher file, hit "merge" and insert the picture and it is done.  It usually takes about 2 to 3 minutes to complete once the template is set up for the agent.